0973-7510 Journal of Pure and Applied Microbiology 2581-690X DR. M.N. Khan 10.22207/JPAM.13.3.34 Natural Products in Drug Discovery: Antibacterial and Antifungal Activity of Essential Oil of Compound Isolated from Senecio royleanus Singh Bisht Chandra Mohan Iqubal S.M. Shakeel A. Khan Aejaz Mohammed Tasneem Dawoud Areej Gamal Mohammed Singh S.K Asghar Basim H Department of Applied Science, IIMT College of Engineering, Greater Noida – 201 301, India Department of General Science (Chemistry), Ibn Sina National College, Jeddah, Saudi Arabia Pharmaceutical Chemistry Department, Faculty of Pharmacy, Jouf University, Skaka 2014, Kingdom of Saudi Arabia Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, AlshaheedShehata Ahmed Hegazy St., 62574 Beni-Suef, Egypt Department of Chemistry, GGV (Central University), Bilaspur, Chhattisgarh – 495 009, India Department of Chemistry, Faculty of Science, Umm Al-Qura, University, Makkah, Saudi Arabia 25 09 2019 13 3 1611 1617 Copyright © 2019 The Author(s) 2019 This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. https://creativecommons.org/licenses/by/4.0/

Natural products are an excellent source of therapeutic products which has led to the discovery of many important drugs that play an important role in the treatment of various human diseases. In this current study two compounds has been isolated from Senecio royleanus DC. (Asteraceae) were undertaken for antibacterial and antifungal activity against five bacterial and fungal pathogens. The compounds isolated from Senecio royleanus, viz; 1,10b-epoxy 6-oxo-furanoeremophilan and 1b, 10-epoxy-furanoeremophilan displayed a very important role against all bacterial and fungal strains. 1,10 b-epoxy 6-oxo-furanoeremophilan showed maximum antibacterial activity against Agrobacterium tumefaciens (13 mm). While it showed maximum fungal activity against Fusarium oxysporum (15 mm). 1b,10-Epoxy-furanoeremophilan was found inactive in antibacterial activity against Escherichia coli, and showed maximum zone of inhibition against bacterial strain of Bacillus subtilis (12 mm) . It showed 12 mm zone against Rhizoctonia solani during antifungal activity. The fractions which showed significant antimicrobial activity i.e. (zoi ³ 10 mm), were further tested to find out minimuminhibitory concentration and minimum bactericidal concentration at different concentrations.

 Keywords Asteraceae/aenecio royleanus Antifungal activity Antibacterial activity