Emergence of Tuberculosis and Multi drug resistance tuberculosis at higher pace in the population needs rapid diagnosis with accuracy to reduce the transmission of disease and suffering of the patients. The technique of GenexpertMTb/Rif by Cepheid rolled out by WHO has given high support to the humanity by rapid and accurate detection of Tuberculosis and resistance to rifampicin. The technique has less turnaround time, can be performed in simple lab settings, fully automated processing and result interpretation and the professional needs a hands on training of less than thirty minutes as compared to other sophisticated techniques for TB and drug resistance diagnosis. The article here discussed the role of CBNAAT in different groups of patients with accordance to the researches already published in support of high and promising performance of GenexpertMTb.