Mucormycosis is an angio invasive infection that occurs due to the fungi mucorales. It is a rare disease but increasingly recognized in immunocompromised patients. It can be categorized into rhino-orbito-cerebral, cutaneous, disseminated, gastrointestinal, and pulmonary types. Overall increased mortality rate is reported, even though the aggressive treatment is given. The main aim and purpose of this review related to overview and Etiopathogenesis of Mucormycosis, fatality of rhinocerebral Mucormycosis, recent advances in diagnostic and treatment methods.