The Zika virus disease represents a great challenge for the medical-scientific community not only because of the association that exists with microcephaly and other congenital anomalies, but also because of the presence of confirmed cases of congenital syndrome associated with Zika in asymptomatic pregnant women, It is very important to carry out a timely detection and diagnosis to evaluate the probability of having an anomaly, the quality of life that the baby will have or the probability of the legal interruption of pregnancy.