The aim of this study was to determine the therapeutic regimen compliance in hemodialysis patients in hospitals of Shahid Beheshti University of Medical Sciences and Health Services in 2010. This study, which was descriptive in nature, consisted of 100 hemodialysis patients who were selected through random sampling method. Tools included a questionnaire consisting of two parts: demographic data and disease. The questionnaire was completed by patients during hemodialysis. In order to determine the therapeutic regimen compliance, the researcher recorded the mean of the last three months’ values of P, K, interdialytic weight gain, and the numbers of missed dialysis sessions using patient’s documents. 78% of patients had missed less than 3 session of dialysis in three month ago, the serum potassium level of 85% of them was up to 5.5 meq/ lit and serum phosphorus level in 64% of them was up to 6 mg/ dl. 87% of the patients were adhered to fluid restricted regimen. 56% of patients had therapeutic regimen compliance. Compliance in hemodialysis patients in hospitals of Shahid Beheshti University of Medical Sciences and Health Services was more than 50 % and it can be said that therapeutic regimen compliance in these patients was acceptable.