ISSN: 0973-7510
E-ISSN: 2581-690X
To investigate the expression of Nrf2 in sepsis rat liver. Methods: Wistar rats were divided into normal control group, S.aureus sepsis combined with Pseudomonas aeruginosa group. According to different phases (2 hours, 8 hours,24 hours), divided into three subgroups, to test the expression of Nrf2 mRNA and protein in liver. Results:high expression of Nrf2 mRNA in normal mouse liver; with increased expression of Nrf2 in Staphylococcus aureus septic rat liver tissue, and increased to peak after 2 hours, and then at 24 hours showed a downward trend. With upregulated expression of Nrf2 at 2 hours in Pseudomonas aeruginosa bacteria septic rat liver tissue and the remaining phases showed downward trend. Conclusion:Nrf2 directly involved in the immune response of sepsis.
Nrf2, sepsis, Pseudomonas aeruginosa, Staphylococcus aureus
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