ISSN: 0973-7510

E-ISSN: 2581-690X

Meng Yu Sheng1,3, Yang Hong Yu1 , Zheng Li Wu2, Yang Hui Jun1, Sheng Shi Yue1, Yang Yuan Yuan1,3, Wang Feng1, 3 and Ma Ping Ping1, 3
1Department of Oral & Maxillofacial Surgery, Peking University, Shenzhen Hospital, Shenzhen – 518 036, China.
2Discipline of Oral Diagnosis & Polyclinics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
3Medical College of Shantou University, Shantou, China.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):33-39
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013
Abstract

This study was to research the different mRNA and protein expression of Toll-like receptors 2 (TLR-2) characteristics in saliary gland benign (SGBT), malignant tumor tissue (SGMT)and saliary gland inflammation (SGI) by the methods of PCR, qRT-PCR and immunohistochemisty. the results showed that, compared with normal tissues, the TLR-2 mRNA expression in salivary gland benign tumor , salivary gland cancer and inflammation tissues were amount to 6.628 fold , 0.432 fold and 8.583 fold respectively (p <0.05). Importantly, we also found that TLR-2 in these organizations not only has a say in the cytoplasm, and the nucleus has expressed only in the SGMT, which was instant differently previous research. This study suggests that there is an variation of TLR2 association between salivary gland tumor, inflammation and NSG. This finding supports a potential role in tumor development, and provide a foundation for development of immune modulation and chemotherapy for SGT.

Keywords

TLR-2, salivary gland tumor, salivary gland inflammation

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