P53 is Tumor suppressor gene which plays a main role in the genomic integrity preservation, mutation in this gene may change the susceptibility of individuals for several viral infections. This work designed to evaluate the effectiveness of P53 gene polymorphism (Arg/Pro) in susceptibility to infection with Molluscum contagiosum and Human Papillomavirus. Thirty one (31) invasive Molluscum contagiosum and 31 invasive Human Papillomavirus cases were studied and compared with 31 matched controls. Striking increase in (Arg/ Arg) and (Arg/ Pro) and decrease of (Pro/ Pro) genotype frequencies have been observed in MCV and HPV infected patients, by comparing with controls, we didn’t find significant relation between this infection and P53 genotypes. By investigate the frequency of mutation (Pro/ Pro vs. Arg/ Arg and Arg/ Pro) we found significant increasing of (Arg/ Arg) and (Arg/ Pro) in MCV infected patients p=0.023<0.05.we found that the carrying of Arg allele be more susceptible to infect with MCV and HPV while Pro/Pro genotype may confer protection against this viruses in our population.