Synthesis of α,β-Unsaturated Carbonyl Compound and Effect on Antifungal and Antibacterial Activity

ISSN: 0973-7510

E-ISSN: 2581-690X

Raymond C. Jagessar¹, S. Gomathinayagam² , N. Balasubramanian³, V. Shanmugaiah³ and P.T. Manoharan⁴

¹Department of Chemistry, University of Guyana, Faculty of Natural Sciences, Turkeyen Campus, Guyana, South America.

²Department of Microbiology, John’s Science Centre, University of Guyana, Guyana, South America.

³Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India.

⁴Department of Botany, Vivekananda College, Madurai, Tamil Nadu, India.

J Pure Appl Microbiol. 2009;3(2):415-420

Received: 05/01/2009 | Accepted: 17/04/2009| Published: 31/10/2009

Abstract

Antimicrobial activity of two a,b-unsaturated carbonyl compounds, aldols were investigated using the agar disc diffusion and poison plate methods. Compounds were synthesized via the aldol route in very good yields and were characterized by ¹H NMR, ¹³C NMR, DEPT-135 and IR spectroscopy. Both compounds were found to be antimicrobial activity. However, their mode of action was more antifungal than antibacterial activity.

Keywords

Antimicrobial Activity, α, β-unsaturated Carbonyl Compounds (Aldols), Agar Well Diffusion, Poison Plate, Spectroscopy

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