Synthesis and Antibacterial Activity of Isatin-3-(isonicotinoyl) Hydrazone and substituted Isatin-3(Isonicotinoyl) Hydrazone

ISSN: 0973-7510

E-ISSN: 2581-690X

S.N. Pandeya¹, Alka Pandey², R.L. Gupta² and Kishu Tripathi¹

¹Saroj Institute of Technology and Management, Lucknow, India.

²Department of Chemistry, Banaras Hindu University, Varanasi, India.

J Pure Appl Microbiol. 2007;1(2):345-349

Received: 18/05/2007 | Accepted: 04/10/2007 | Published: 30/10/2007

Abstract

Isatin-3-(isonicotinoyl) hydrazone and substituted isatin-3(isonicotinoyl) hydrazone were synthesized and their antibacterial activity was screened. It was observed that the Mannich base with methtyl, isopropyl and isobutyl group substituted Istain –3 -(isonicotinoyl) hydrazone exhibited higher activity and inhibit the growth of almost all the tested bacteria. Among the series, the least active was the compound residues and the methyl derivative (II-20) is the most active.

Keywords

Istain-3-(isonicotinoyl) hydrazone, antibacterial activity

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