Breast cancer is a major women health problem and second leading cause of cancer related death in worldwide. The purpose of study to find out the disease in early stage. The study was conducted to assess pattern of changes in BMI, lipid profile and CBC in women having breast cancer. There are 2 groups. One is healthy women and second is case group. Fasting blood sample of 75 breast cancer as case group and 75 healthy individual as control group were investigated for lipid profile (HDL-C, LDL-C, TG) and Hematological parameters (Hb, WBC, RBC, Platelets). BMI was measured in each of the patients and control. In the lipid profile,TC and HDL-C was measured by direct enzymatic method, TG by GPO-POD method, LDL-C by friedwald formula. These were measured enzymatically on the Hitachi 902 fully autoanalyzer. The hematological parameters were measured by the cell counter analyzer. Result shows significant increase in LDL, TG and BMI levels of case group when compared to control. In contrast HDL-C level decrease in case group when compared with control. It was observed that the significantly elevated in BMI, LDL-C and TG of the breast cancer patients compared to control. Increased levels of the hematological parameters predict the disease severity and mortality risk. The BMI, Lipid Profile and hematological parameters are common feature to be considered in breast cancer patients which could be useful tool in diagnosis and monitoring treatment. We can suggest that combination of BMI, Lipid profile and hematological parameters could be used as an important biochemical parameters for breast cancer patients, there are cost effective and can be easily assayed in smaller laboratories not yet exposed to any sophisticated technology for more reliable cancer marker.