Stenotrophomonas maltophilia (Sm) is endowed with immense prowess that can be exploited  beneficially in Agriculture, Nutrition, Medicine, Biodegradation, Bioremediation and Phytoremediation. The bacterium possesses multitudinous extracellular proteins and enzymes lined by inherent and acquired mechanisms and/or genes which are primarily responsible for adaptation and survival in its niche. Accessibility to the versatility and synthetic dynasty embedded in the bacterium is however threatened by ease of contamination with toxic product(s) of the same bacterium and the bacterial implication in life threatening multidrug resistant infections promoted by the presence of resistance genes. High level technology and expertise, with collaboration by scientists from all wards of life is advocated to safely harness the biotechnological potentials of the organism at an economically viable magnitude.