Zainab A. Aldhaher1, Batool Hassan Al-Ghurabiand
Baydaa Hussein Alwan3

1Department of Basic Science, College Of Dentistry, University of Baghdad, Iraq.
2Medical Microbiology, Clinical Immunology, Department of Basic Science, College of
Dentistry, University of Baghdad, Iraq.
3Department of Biology / College of Science, Al-Mustansiriyah University, Iraq.

Abstract

Both rheumatoid arthritis and periodontitis are complex multifactorial disorders, characterized not only by a dysfunction of basic inflammatory and tissue destructive mechanisms, but also by an altered adaptive and innate immune response in individuals. IL-22 plays an important role in inflammation, including chronic inflammatory diseases and infectious diseases. This study aimed to evaluate the serum levels of IL-22 and ACPA in RA patients. The study included 45 rheumatoid arthritis patients and 35 apparently healthy controls.  Enzyme-linked immunosorbent assay (ELISA) has been used for estimation the levels of IL-22 and ACPA in serum of two studied groups. The present results revealed that mean serum levels of IL-22 and ACPA were significantly higher in patients than in healthy controls (p<0.02, p<0.04) respectively.  On the other hand, there is no correlation was found between serum level of antibody (IgG-ACPA) and serum level of cytokine (IL-22), (r=0.79; p=0.606). Elevation serum level IL-22 could be involved pathogenesis of RA in association with ACPA level.

Keywords: rheumatoid arthritis, Cytokines, IL-22, ACPA.