The study was conducted on the wheat plant Triticum aestivum L in order to determine the effect of nitrogen (N) and nitric oxide (SNP) on nickel (Ni) and reducing its toxicity in the plant. The experiment was carried out in College of Science laboratories, King Saud University, and the following factors has been applied. The wheat was planted in a plastic pots measuring (20 × 20 cm) each pot contains about 15 pills. The randomized complete blocks design was followed with three replications, each replicate includes three pots, data were analyzed using statistical analysis software (SPSS) and averages was compared by testing less significant difference LSD at 5% significance level. The results showed that nickel reduced plant height and leaf area, but it led to increase the amount of peroxides and catalysis and cause little reduce in wet and dry weight of the plant. Also it was found that the nitrogen and nitric oxide increases the length of the plant, the vegetative area, the wet and dry weight and the quantity of each of peroxides and catalysis which mean they reduced the toxicity of nickel and its impact on the mentioned qualities.