In search for sustainable agricultural methods for medicinal plants. A field experiment was conducted at the College Agronomy Farm, Anand Agricultural University, Anand, Gujarat during rabi season of 2013-14. The experiment consisted of eighteen treatment combinations comprised of three nitrogen levels (15, 30 and 45 Kg N ha­^-1), three phosphorus levels (0, 15 and 30 Kg P ha­^-1) and two potassium levels (0 and 30 Kg K ha­^-1). The treatment N₃ (45 kg N ha^-1) recorded significantly the maximum seed  and straw  yields as well as plant height at harvest, no. of effective tiller plant^-1, no. of effective spikelet plant^-1 and test weight of 1000 seeds and significantly higher length of spike as compared to other nitrogen treatments i.e. N₁ (15 kg N ha^-1) and N₂ (30 kg N ha^-1). Significantly higher seed and straw yields as well as plant height at harvest and no. of effective spikes plant^-1, while no. of tiller plant^-1 showed the significantly higher – response by application of 30 kg P₂O₅ ha^-1, other characters like length of spikes and test weight of 1000 seeds and swelling factor found to be non-significant response. The response on growth and yield attributing characters as well as seed and straw yields of isabgol were also found non-significant due to different potassium levels. On economical point of view when isabgol treated with 45 kg N ha^-1, 30 kg P₂O₅ ha^-1  and 30 kg K₂O ha^-1 noted higher net realization as compared to other treatment.