C-reactive protein (CRP) in the form of high sensitivity CRP (hs-CRP) is one of the better extensively used risk marker for the coronary artery disease (CAD) in clinical practice. Increased value of hs-CRP has been related with increased threat for the development of blood pressure, stroke, peripheral arterial disease, temporary ischemic attack and sudden coronary deceased condition. If hs-CRP involves a fundamental role in atherothrombosis, then hs-CRP is the better biomarker proposed to be necessary for improving to detect the risk of coronary events of arterial disease. In this study, the HCV seropositive patients (by Anti HCV-IgG Indirect Elisa) more than 2 years old, hepatic and leukaemia were investigated for extra hepatic manifestation. The Lab request forms with questionnaire were together including CRP, HS-CRP, serum cholesterol and liver function tests were scrutinized. Total of 170 cases (around the Chennai) was taken for the study. In which, 45.3% of cases were observed as hepatitis patients with ALL cases. The other 8% of cases were having liver cirrhosis and rest of the cases was not having cirrhosis. Finally, the study explores the relationship between the HCV seropositive of leukaemia cases, HCV RNA and CRP, hs CRP with cirrhosis. These evaluations point out that HCV infection may amend the chronic inflammatory condition in leukaemia patients. Additionally, the results recommended that screening for hs-CRP should be considered previous to evaluation of cardiovascular risk in HCV patients, because the results may affect the risk scoring of coronary artery disease.