ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Abdulhakim Bawadekji1 , Mohd. Imran2, M.A.U. Mridha3 and Mouhanad Al Ali4
1Department of Biological Sciences, College of Science, Northern Border University, P.O. Box 1321, Arar – 91431, Saudi Arabia.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, P.O. Box 840, Rafha – 91911, Saudi Arabia.
3Department of Environmental Management, School of Environmental Science and Management Independent University, Dhaka – 1229, Bangladesh.
4Universitי d’Angers, Institut Supérieur de la Santé et des Bioproduits d’Angers, Angers – 49045, France.
J Pure Appl Microbiol, 2019, 13 (3): 1483-1488 | Article Number: 5815
https://doi.org/10.22207/JPAM.13.3.19 | © The Author(s). 2019
Received: 23/08/2019 | Accepted: 18/09/2019 | Published: 29/09/2019
Abstract

Antimicrobial resistance (AMR) is the existing global apprehension for the social health. There is a requisite to take counteractive actions regarding the AMR. Based on the literature, it was aimed to perform the phytochemical and antimicrobial activity evaluation of the water immiscible solvent extracts of Moringa peregrina Forssk. Fiori (Family: Moringaceae). Seven extracts of the powdered leaves of M. peregrina were prepared in solvent systems comprising dichloromethane (DCM), dichloroethane (DCE), and their mixtures with ethyl acetate (EA) and chloroform (CH). The extracts were screened for their phytochemicals and antimicrobial potential. All the extracts showed positive tests for alkaloids, saponins, and flavonoids, wherein negative tests were obtained for tannins, cardenolides, and anthraquinone glycosides. The 1:1 mixture of EA:DCM, and EA:DCE provided positive tests for steroids and terpenoids. The most effective antimicrobial extracts were the 1:1 mixture of EA:DCM and EA:DCE. However, the antimicrobial activity of these extract was mild in comparison to ofloxacin and fluconazole. It is concluded that various mixtures of DCM, DCE, and CH along with the higher concentration of other miscible solvents of DCM, DCE, and CH may provide better antimicrobial extracts.

Keywords

Moringa peregrina, Leaves, Water immiscible solvent, Extract, Antibacterial, Antifungal.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.