Endophytic actinomycetes especially Streptomyces are the most wanted genera in Biopharamaceutical industries.  Inside the plants they plays critical role which promotes growth.   Endophytic biology would be the new microbial niche is needed to explore more especially for Streptomyces genera.  Their genetic co-evaluation with plants can create novel chemistry and its ability of producing plant chemicals has raised its importance to combat against various drug resistance organisms and to reduce the over harvesting of the plants.  The current review describes the need of endophytes isolation from antimalarial ethanobotanical valued plants and its important chemicals also concentrated.  Majorly, this report discusses the rational approach on selecting medicinal plants for endophytic Streptomyces against the specific disease.