Management of anthracnose, a post harvest disease of mango (Mangifera indica L.) incited by Colletotrichum gloeosporioides (Penz.) Penz. & Sacc.  was produced by using native antagonistic microflora. Under in vitro study, the Trichoderma isolates Trichoderma fasciculatum and Trichoderma koningii showed the highest antagonistic activity against Colletotrichum gloeosporioides in dual culture isolated from fructoplane and phylloplane respectively. T.fasciculatum proved to be the best compatible antagonist with different fungicides evaluated. In vivo screening of potential antagonist T.fasciculatum on mango fruits revealed that post-inoculation (pre-treatment) method is superior over the pre-inoculation method in management of anthracnose disease. The possibility of exploitation of fungicidal compatible bioagent in the integrated management of anthracnose with low fungicidal residue will delay in development of resistance in the pathogen will be discussed.