Laboratory experiments were conducted in bio-control laboratory, SVPUA&T, Modipuram during 2011-12 and 2012-13 to evaluate the effectiveness of entomopathogenic fungi (EPF) Beauveria bassiana, Metarhizium anisopliae, entomopathogenic nematodes(EPN) Heterorhabditis indica and one insecticides Chloroyriphos20 EC against white grub Holotrichia nagpurensisdamaging sugarcane. On the basis of average cumulative grubs mortality during 2011-12 and 2012-13 the treatment H. indica1000 IJsml^-1 (4.0×10⁹) was found the superior as compared to the other bio agents and recorded 62.78 percent and 62.45 percent decrease in grub population, respectively. The treatment H. indica 2000 IJs ml^-1 (5.0×10⁹)resulted in 61.66 and 61.94 percent, chloropyriphos 20 EC 58.05 and 60.83 percent, Beauveria bassiana (2×10⁸) 44.44 and 47.22, Metarhizium anisopliae (2×10⁸) 34.44 and 32.77 percent, Beauveria bassiana x Metarhizium anisopliae (2×10⁸) 29.72 and 28.61, Metarhizium anisopliae (2×10⁶) 21.44 and 21.11 percent, Beauveria bassiana x Metarhizium anisopliae (2×10⁶) 13.33 percent decrease in grub population, respectively. The lowest grub mortality was recorded 6.11 percent and 7.49 percent decrease in grub population by the treatment B. bassiana (2.0×10⁶ sporesg^–1). According to the findings the application of H. indica 1000 IJsml^-1 (4.0×10⁹) is recommend to manage the grub population effectively.