The present study aims to explore the influence of early oral refeeding on triglyceride (TG) in patients with mild acute pancreatitis. Eligible patients were randomly divided into the early refeeding group (ER, n=80) and late refeeding group (LR, n=77). Both groups received conservative treatment. Patients started refeeding just when they felt hungry in ER group. In LR group, patients didn’t restart eating until their serum amylase and lipase decreased to 2 times the upper limits of reference values, the abdominal distension and pain was disappeared with normal bowel sounds. There were 31 patients in ER group and 26 in LR group who’s TG were higher than 2.24mmol/L before refeeding. At the time of pre-discharge after refeeding, the number of patients whose TG level decreased were 24 in ER group and 13 in LR group (p=0.0307). (2)There were 24 patients in ER group and 12 in LR group who’s TG were higher than 4.48 mmol/L before refeeding. At the time of pre-discharging, the number of patients whose TG were less than 4.48mmol/L was 20 in ER group and 5 in LR group (p=0.0015).(3)The mean refeeding time was 4.63 days in the ER group and 6.83 days in the LR group, respectively (p<0.05). It was concluded that early oral refeeding is beneficial for lipid control in mild acute pancreatitis with hypertriglyceridemia.