J Pure Appl Microbiol | Research Article | Volume 12, Issue 4 | Article Number: 5283

Oday S. Abbas1*, Dalia A. Abdul-Shaheed2 and Rand M. Anwer1

1Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq,
2College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.

Corresponding Author E-mail: droddr7757@gmail.com
Received: 13/07/2018| Accepted: 30/09/2018 |Published: 17/12/2018
DOI: http://dx.doi.org/10.22207/JPAM.12.4.16

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Abstract

Mycotoxins are microbial agents which cause food or feed-borne intoxications. Mycotoxins are undesirable compounds often found in cereal grains and forages. Ochratoxin A (OTA) is mycotoxin creates by more than a few type of Aspergillus in addition to Penicillium and can cause benign and/or malignant tumors. Due to that, this study was planned to induce cancer in mice mammary gland by (OTA). Twenty mice were caged to tow experimental groups and treated (10ppb OTA) for 6 months. The results showed that the mammary gland gross appearance gave enlargement with irregular shape while the histopathological changes showed pleomorphic hyperchromatic malignant cells indication for malignant adenocarcinoma of mammary gland.  These results clearly indicated that OTA has carcinogenic compound that cause cancer in mammary gland of mice.

Keywords: Mycotoxins, Ochratoxin A, Carcinogenic effects, Fungal contamination.