The incidence of different bacterial pathogens and their antibiogram profile isolated from septic patients from Bhubaneswar was studied from March 2009 to October 2009. Out of 155 patients 92.26% were culture positive for different bacterial pathogens. Bacteriological analysis of the culture positive cases revealed 27.27% were Staphylococcus aureus, Streptococcus pyogenes-8.39%, other Staphylococcus species-8.39%, Pneumococcal species-3.5%, E.coli-11.9%, Klebsiella species -9.8%, Pseudomonas species -4.9%, Serratia species-2.8%, Proteus species-0.7% and gram positive rods-7.7%. Staphylococcus, Klebsiella and Pseudomonas were resistant to most of the antibiotics. Bacteriological analysis with septic patients is highly essential for the treatment and management of these patients in this area. This type of study should be continued in other parts of Odisha including more number of patients.