Various bio agents and fungicides were tested in vitro against Pyricularia setariae which causes leaf blast in foxtail millet. Among fungal antagonists, all the Trichoderma spp tested overgrew on the pathogen and showed cent per cent of mycelia inhibition. Among the bacterial antagonists, Bacillus cereus showed 81.14 per cent mycelia inhibition followed by B. subtilis (80.26%). Among the contact and combi-products cent per cent inhibition was observed in mancozeb, carbendazim + mancozeb, carboxin + thiram and tebuconazole + trifloxystrobin at 500, 1000 and 2000 ppm. Whereas, in systemic fungicides, Cent per cent inhibition of mycelia growth was recorded in hexaconazole, penconazole, propiconazole and tebuconazole at all the concentrations tested (50, 100 and 200 ppm).