Olufunmiso O. Olajuyigbe1,2*, Morenike O. Adeoye-Isijola1, Babasola A. Osopaleand Roger M. Coopoosamy2

 1Department of Microbiology, Babcock University, PMB 4005, Ilisan Remo, Ogun State, Nigeria.
2Department of Nature Conservation, Faculty of Natural Sciences, Mangosuthu University of Technology, Umlazi, Durban, South Africa.

ABSTRACT

To investigate the in vitro effects of interactions between ciprofloxacin (CP) and magnesium-aluminium hydroxide (MA) combined against selected Gram-positive and Gram-negative bacteria. The interaction between CP and MA was accessed by agar diffusion method. Comparing the susceptibility of the isolates to CP alone with those of Ciprofloxacin-Magnesium-aluminum hydroxide (CPMA) combined showed that there were significant antagonistic and synergistic interactions in vitro. Antibacterial activities of ciprofloxacin were increased with 4.5-6.0 µg/ml of the MA but were drastically decreased with concentrations lower and higher than 4.5-6.0 µg/ml while development of resistant colonies within these zones of inhibitions was recorded. The susceptibility of the isolated resistant colonies was lesser than those obtained from the original isolates. The combination of ciprofloxacin (CP) and magnesium-aluminum hydroxide (Maalox) (MA) against bacterial isolates could result in development of resistant colonies. The roles of aluminum and magnesium in resistance development at the molecular level require further studies.

Keywords: Ciprofloxacin; ciprofloxacin-magnesium-aluminum hydroxide; antagonistic interactions; polyvalent metallic ions; resistance development.