The balsam “liquid storax” of Liquidambar orientalis Mill. that (Sigla) is an endemic tree species for Eastern Mediterranean, was obtained from Günnücek (Marmaris). It was extracted with n-hexane, CH₂Cl₂ and MeOH respectively. The n-hexane, CH₂Cl₂, MeOH extracts were tested at concentrations of 10.0%, 1.0%, 0.4%, 0.2% and 0.1% against two different groups of bacteria: Pathogens and marine biofilm bacteria. Klebsiella pneumonia, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeroginosa, Bacillus cereus, Enterococcus faecalis and Candida albicans were used as pathogen microorganisms whereas, Pseudoalteromonas marina P. haloplanktis, Alteromonas alvinella, Alteromonas genoviensis Vibrio splendidus, Exiguobacterium homiense, Vibrio lentus were used as marine biofilm bacteria. The antimicrobial test results showed that the MeOH extract of storax has more potent antimicrobial activity than CH₂Cl₂ and n-Hexane extracts. Inhibitory activities of L. orientalis resin extracts were high against biofilm bacteria, while they were found to be low against pathogenic microorganisms tested.