ISSN: 0973-7510
E-ISSN: 2581-690X
The study aimed to investigate antiviral properties of orange peel methanolic extract against herpes simplex virus type 1 and 2 (HSV-1 and 2) in vitro. HSV-infected Vero cells and cell-free virus suspensions were treated with orange peel extracts, and virus yield and infectivity were quantified by direct plaque assay. The results of the present study showed that orange peel methanolic extract at 100µg/ml provided 68.5% inhibition against HSV-1. In addition, orange methanolic extract at 100 µg/ml provided 72.8% inhibition against HSV-2. The extract showed 100% inhibition against HSV-1 and 2 at 200, 250 and 300 µg/ml. These properties suggest that this orange peel could provide advantage as a topical prophylactic/therapeutic agent for herpes infections.
Antiviral, Orange peel, Herpes simplex virus
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