This study investigated whether pigment epithelium derived factor (PEDF) combined with lens injury protection coordination of rat retinal ganglion cells (RGCs) survival and promote RGCs axonal regeneration purposes, using Fluoro-Gold microinjection into adult SD rats and 2 W SD was born in brain of young rats, retrograde labeled RGCs and preparation of optic nerve injury models and crystalline lens injury model, observation number method, draw a result, intravitreal injection of PEDF lens injury can increase RGCs survival number, both of which can be coordinated so that this role increased. Lens injury stimulates axon regeneration, combined with PEDF can enhance the stimulation of regeneration. Lens injury and PEDF can improve GAP-43 mRNA expression, the combination of the two makes this action to strengthen.
Retinal ganglion cells, Lens injury, Pigment epithelium derived factor, Axon, Regeneration, Opticnerve injury
© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.