ISSN: 0973-7510

E-ISSN: 2581-690X

Jin-Yuan Wu , Feng-Yuan Sun, Dong-Run Tang and Rui Zhang
1Department of Ophthalmology, Tianjin First Center Hospital, Tianjin, China.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):289-296
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013
Abstract

This study investigated whether pigment epithelium derived factor (PEDF) combined with lens injury protection coordination of rat retinal ganglion cells (RGCs) survival and promote RGCs axonal regeneration purposes, using Fluoro-Gold microinjection into adult SD rats and 2 W SD was born in brain of young rats, retrograde labeled RGCs and preparation of optic nerve injury models and crystalline lens injury model, observation number method, draw a result, intravitreal injection of PEDF lens injury can increase RGCs survival number, both of which can be coordinated so that this role increased. Lens injury stimulates axon regeneration, combined with PEDF can enhance the stimulation of regeneration. Lens injury and PEDF can improve GAP-43 mRNA expression, the combination of the two makes this action to strengthen.

Keywords

Retinal ganglion cells, Lens injury, Pigment epithelium derived factor, Axon, Regeneration, Opticnerve injury

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