ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Jesse Joel T. , Jagadish Kumar Suluvoy and Jency Varghese
Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641 114, Tamil Nadu, India.
J Pure Appl Microbiol, 2019, 13 (3): 1667-1672 | Article Number: 5747
https://doi.org/10.22207/JPAM.13.3.40 | © The Author(s). 2019
Received: 03/06/2019 | Accepted: 27/07/2019 | Published: 28/09/2019
Abstract

Cancer is life threatening disease which decrease the quality of the human life and the available medicine to treat the cancer has adverse side effects. The current investigation is to uncover natural products to treat cancer without any side effects. Punica granatum L. (Pomegranate) belongs to the family fruit-bearing deciduous small plants with unique flavour, taste, nutritionally rich and popular in health promoting characteristics. P. granatum L peels were collected and extracted for phytochemicals analysis using solvent ethanol and the preliminary analysis revealed the presence of phytochemicals. The analytical GC-MS was carried out to confirm the phytochemicals with pharmacologically and biologically active compounds. The anticancer activity of the extract was carried out against oral cancer cell line (KB 3-1) and this peel extract exhibited promising anticancer property. The MTT assay showed 94.53% inhibition on the oral cancer cell line and clonogenic assay showed decrease in the colonies after treating with the peel extract. These showed positive and encouraging results with efficient anticancer properties and further studies can help identify novel compounds with pharmacological properties for effective cancer treatment.

Keywords

Punica granatum L, phytochemicals, GC-MS, MTT, clonogenic assay, pharmacological.

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© The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.