The microwave exposed cultures during 48 hr. accumulated more oxytetracycline (OT) titers which was highest having an antibiotic titre of 380 µg/ml as against 24 hr exposed sample and control with 310 µg/ml of antibiotic titre. There is distinct change in the mode of action of antibiotic, with a clear spheroblast formation at the periphery of the zone of inhibition of the test organism Bacillus cereus as evidenced by scanning electron microscopic studies. The present report represents the first description of the microwave exposure inducible property and as such provides some insight into the stress response as evidenced by the heat shock protein profile and physiologically complex Streptomyces species, which produces oxytetracycline, a secondary metabolite.
Oxytetracycline, Heat Shock, Microwave, Streptomyces sp
© The Author(s) 2007. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.