Enhanced Antimicrobial Activity of a Supramolecular System Formed via Hydrogen Bonding Interaction of a 5, 10, 15, 20 Meso tetrakis Pentafluorophenyl 21H, 23H Porphine with Mesoporphyrin (ix) Dihydrochloride

ISSN: 0973-7510

E-ISSN: 2581-690X

Enhanced Antimicrobial Activity of a Supramolecular System Formed via Hydrogen Bonding Interaction of a 5, 10, 15, 20 Meso tetrakis Pentafluorophenyl 21H, 23H Porphine with Mesoporphyrin (ix) Dihydrochloride

Subramanian Gomathinayagam¹ and R.C. Jagessar²

¹Department of Microbiology, John’s Science Centre, Faculty of Agriculture and Forestry, Berbice Campus, John’s, University of Guyana, South America.

²Department of Chemistry, University of Guyana, Faculty of Natural Sciences, Turkeyen Campus, Guyana, South America.

J Pure Appl Microbiol. 2011;5(1):31-37

Received: 27/06/2010 | Accepted: 12/08/2010| Published: 30/04/2011

Abstract

Antimicrobial activity of a supramolecular system resulting from hydrogen bonding interaction of mesoporphyrin(ix )dihydrochloride (3) with 5, 10, 15, 20 – meso tetrakis pentafluorophenyl 21H, 23H porphine (4) was investigated using the Agar diffusion and Poison plate methods. Compound (5) was shown to display enhanced antimicrobial activities against S. aureus, C. albicans and E. coli in comparison to that of either (3) or (4), synthetic ampicillin and nystatin.

Keywords

Enhanced Antimicrobial activity, hydrogen bonding, supramolecular Chemistry, Agar well diffusion, Poison plate method

Download PDF

Article Metrics

Article View: 550

JPAM.5.1.05 (176 downloads)

Share This Article

© The Author(s) 2011. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.