Detection of Interaction Between DsbM and OhrR by Yeast Two-hybrid System in Pseudomona aeruginosa

ISSN: 0973-7510

E-ISSN: 2581-690X

Detection of Interaction Between DsbM and OhrR by Yeast Two-hybrid System in Pseudomona aeruginosa

Mingxuan Li, Xinyu Guan, Xuehan Wang, Haijin Xu and Mingqiang Qiao

¹State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences,
Nankai University, Tianjin, 300071, P. R. China.

J Pure Appl Microbiol. 2014;8(1):601-605

Received: 30/10/2013 | Accepted: 05/12/2013 | Published: 28/02/2014

Abstract

DsbM and OhrR proteins are encoded by the P. Aeruginosa genes dsbM and ohrR, respectively. We found a strong interaction between DsbM and OhrR proteins by yeast two-hybrid system. This result indicated the correlation between DsbM which affects the aminoglycoside resistance and the ohrR regulon in Pseudomonas aeruginosa. Our findings showed important implications for studying the aminoglycoside resistance in Pseudomonas aeruginosa in future.

Keywords

DsbM, OhrR, Yeast two-hybrid

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