J Pure Appl Microbiol | Review Article | Volume 13, Issue 1 | Article Number: 5506

Shailza Shreshtha1, Pradeep Kumar1, Preeti Sharma1* and Rachna Sharma2

1Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad – 201 001, India. 2Department of Biochemistry, TSM Medical College and Hospital, Lucknow – 226 003, India.
Corresponding Author E-mail: prcdri2003@yahoo.co.in
Received: 17/01/2019 | Accepted: 01/03/2019 | Published: 28/03/2019
DOI: http://dx.doi.org/10.22207/JPAM.13.1.14

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ABSTRACT

Cytokine release syndrome (CRS) is a life threatening toxicity associated numerous immunotherapeutic techniques involving monoclonal antibodies, bispecific antibodies and adoptive T cell therapies. It is also referred as infusion reaction that results in release of large amount cytokines (Like IL-6, IFN-r, INF) from the target cells. Cytokines when released in excessive amounts into the circulation produces systemic symptoms like nausea, shills, fever, rashes, headache, hypotension, dyspenea etc. Most of the patients present mild to moderate symptoms which can be managed easily but some patients show life threatening symptoms. Studies have shown that immunosuppressive agents like corticosteroids and tocilizumab can reverse the toxicity of CRS, however such immunosuppression may limit the immunotherapeutic efficacy. Therefore specific precautions must be considered in such patients to present exacerbation of the complication. Thus this review is based on the overview of CRS which include etiology, mechanism and management of CRS, so that immunotherapeutic benefits can be maximized with minimum risk of complication.

KEYWORDS 

Cytokine release syndrome, monoclonal antibodies, chimeric antigen receptor modified T- cells, cortiocsteroids, tocilizumab.

Citation: Shailza Shreshtha, Pradeep Kumar, Preeti Sharma and Rachna Sharma, Cytokine Release Syndrome: An Overview on its Features and Management, J Pure Appl Microbiol., 2019; 13(1):133-140 doi: 10.22207/JPAM.13.1.14

 


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