Calcium Channel Blocking and Anti-arrhythmic Activities of Some Thienopyrimidine with Benzoxazine, Quinazoline and Azole Moieties

ISSN: 0973-7510

E-ISSN: 2581-690X

Mohamed M. Abdalla¹ , Abd El-Galil E. Amr^2,3, Mohamed G. Assy⁴ and Zainab M. Ramadan⁴

¹Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt.

²Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC),
College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

³Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.

⁴Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

J Pure Appl Microbiol. 2014;8(5):3773-3780

Received: 06/08/2014 | Accepted: 20/09/2014 | Published: 31/10/2014

Abstract

In our previous work, some of thienopyrimidine, benzoxazine, quinazoline and azole moieties 1-18 were synthesized before. We herein report the calcium channel blocking and anti-arrhythmic activities. Nineteen of these compounds were screened for their calcium channel blocking and anti-arrhythmic activities using of Nifedipine as the reference drug. The newly synthesized compounds showed potent calcium channel blocking and anti-arrhythmic activities with low toxicity (LD₅₀) comparable to Nifedipine as reference drug.

Keywords

Thienopyrimidinoyl chloride, Thienopyrimidine, Benzamidazole, Calcium channel blocking, Anti-arrhythmic activities

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