SNPs in candidate genes for immune response DC-SIGN and SP110 have been reported for resistance /susceptibility to tuberculosis in humans as well as in animals. They are potential strong candidates for investigating genetic basis of disease resistance. Therefore the objective of this study was to explore the association of SNPs to susceptibility and resistance against TB infection in cattle. In case of SP110 gene both SNPs under study (rs41256732 and rs134537150) revealed polymorphism. Whereas in case of DC-SIGN gene two of SNPs (rs137338039 and s208436798) were found to be polymorphic while one SNP (rs134731570) revealed monomorphism. These findings point to the presence of these SNPs in our resource population. However, for the SNPs under investigation, the genotype as well as allele had nonsignificant effect on occurrence of bovine tuberculosis. Heterozygosity, PIC and allelic diversity values were estimated as low for rs208436798 while corresponding values for other SNPs were observed as moderate. Apart from rs134537150, the population was not in HWE for all the other the SNPs studied. In conclusion none of the SNPs studied were found to be associated but further validation in independent, large resource population and biological characterization are warranted with more effective case-control identification.