Journal of Pure and Applied MicrobiologyVol. 1 No. 2

Plasmid curing activity of plumbagin and its application in bacterial antibiotic resistance

V. P. Zambare*, P. S. Kothari and M.V. Kulkarni

School of Life Sciences, North Maharashtra University, Umavi nagar, Jalgaon, India.

Received on 19 June 2007 and accepted on 16 July 2007

 

ABSTRACT

Plumbago zeylanica, a medicinal plant, contain plumbagin a naphthoquinonic compound. Partially purified plumbagin was tested for its plasmid curing activity. E. coli, isolated from pathological samples showed multiple antibiotic resistance. Plumbagin showed antibacterial activity at MIC value; 80 mg ml-1. Antibiotics and plumbagin together decreased the antibiotic resistance pattern, suggesting plasmid curing by plumbagin. Thus, plumbagin can be used as an adjuvant to antibiotic therapy for treating infectious diseases caused by antibiotic resistant organisms.

Keywords : Plumbago zeylanica, plasmid curing, plumbagin, antibiotic resistance.