Journal of Pure and Applied MicrobiologyVol. 1 No. 2

Antimicrobial Activity of 1-substituted-2-thio- (1h)-4 (1-substituted thiocarbamido-3-yl)-6-substituted amino 1,2-dihydro-s-triazine.

M.E. Shelke

Department of Chemistry, H.V.P.M. College of Engineering and Technology, HVPM Campus, Amravati, India.

Received on 22 May 2007 and accepted on 02 July 2007

 

ABSTRACT

Novel series of 1-substituted-2-thio-(1H)-4-(1-substitutedthiocarbamido-3-yl)-6-substitutedamino 1,2-dihydro-s-triazines[3a(I) to 3f(III)] have been obtained by the isomerisation of 2-substitutedamino-4-(1-substitutedthiocarbamido-3-yl)- 6-substitutedimino-1,3,5-thiadiazines[2a(I) to 2f(III)] in presence of ethanolic sodium bicarbonate solution, which have been obtained by basification of their hydrochlorides [1a(I) to 1f(III)] which are synthesized by the interaction of 1,3-Bis-(n- substitutedthioamido) guanidine and N-aryl/alkylisocyanodichlorides. The latter were prepared initially by the condensation of guanidine carbonate and N-substitutedisothiocyanate. The structure of all these compounds was established on the basis of elemental analysis, IR and PMR spectral data. All the synthesized compounds have been screened for their antimicrobial activity against both gram-positive and gram-negative human pathogens.

Keywords : 1,3-Bis-(n- substitutedthioamido) guanidine, 1,3,5-thiadiazines, antimicrobial activity.