Journal of Pure and Applied MicrobiologyVol. 1 No. 2

Synthesis and Antibacterial Activity of Isatin-3-(isonicotinoyl) Hydrazone and substituted Isatin-3(Isonicotinoyl) Hydrazone

S.N. Pandeya1, Alka Pandey2, R.L. Gupta2 and Kishu Tripathi1

1Saroj Institute of Technology and Management, Lucknow, India. 2Department of Chemistry, Banaras Hindu University, Varanasi, India.

Received on 18 May 2007 and accepted on 04 October 2007



Isatin-3-(isonicotinoyl) hydrazone and substituted isatin-3(isonicotinoyl) hydrazone were synthesized and their antibacterial activity was screened. It was observed that the Mannich base with methtyl, isopropyl and isobutyl group substituted Istain 3 -(isonicotinoyl) hydrazone exhibited higher activity and inhibit the growth of almost all the tested bacteria. Among the series, the least active was the compound residues and the methyl derivative (II-20) is the most active.

Keywords : Istain-3-(isonicotinoyl) hydrazone, antibacterial activity.