Journal of Pure and Applied MicrobiologyVol. 9 No. 3

Effect of Exchange Transfusion in Biochemical Parameters in Neonatal Hyperbilirubinemia

Manishi Singh1, Manika Singh2, Surya Tiwari3 and M.P. Singh4

1Chirayu Medical College and Hospital, Bhopal, India. 2SR, Mansarovar Dental College, Bhopal, India. 3Tutor, Chirayu Medical College and Hospital, Bhopal, India. 4Professor and HOD, PCDS, Bhopal, India.

Received on 10 June 2015 and accepted on 09 August 2015



Hyperbilirubinemia is very common and usually benign in the term newborn infant and late pre-term infant at 35-36 completed weeks’ gestation. Critical hyperbilirubinemia is uncommon but has the potential for causing long term neurological impairment. The present study is designed to determine the effect of exchange transfusion in biochemical parameters in pre-term and full term infants. Sixty newborns who underwent double volume exchange transfusion for different indications were studied. The infants were divided into two groups, Group A containing Full term infants and Group B containing Preterm infants. Blood samples were obtained and the following tests were performed i.e. serum bilirubin and blood glucose. A significant (p<0.001) decrease in serum bilirubin values was observed in both the groups after exchange transfusion. Also a significant (p<0.001) elevation of blood glucose level when measured at 5 min. after exchange transfusion and rebound decrease in blood sugar levels when assessed 3 hours post exchange was documented in both the groups.

Keywords : Hyperbilirubinemia, jaundice, Pre-term newborn, Term-newborn, Exchange Transfusion.