Journal of Pure and Applied MicrobiologyVol. 1 No. 2

Synthesis and Antifungal Activity of 4-amino-5-aryl-1, 2, 4-triazoles

Umesh Kumar1*, M. Bansal2, Shiv K. Gupta2 and M. Saharyar3

1Department of Pharmaceutical Science, Shree Ganpati Institute of Technology, Ghaziabad, India. 2KIET School of Pharmacy, Ghaziabad–Meerut Road, Ghaziabad - 201 206, India. 3 Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

Received on 06 February 2007 and accepted on 15 March 2007

 

ABSTRACT

A few 4-amino-5-aryl-1, 2, 4-triazoles were synthesized and tested for antifungal activity against Aspergillus niger and Candida albicans. 4-amino-5-aryl-1, 2, 4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted Dithiocarbazinic acid with Hydrazine hydrate. The new synthesized compounds were characterized using IR Spectra, 1H NMR and elemental analysis.

Keywords : 1, 2, 4- Triazoles, Antifungal activity, IR, 1H-NMR.