The present chemical studies include applicable work to reveal activity of two anti-parasitic and anti-bacterial-compounds against resulted contaminators; including species of protozoan-parasites and coliform bacteria, that isolated from Rafha City. The present resulted protozoan parasites including cysts of Giardia lamblia, Cryptosporidium parvum and Entamoeba coli whereas isolated coliform bacteria-species are Proteus mirabilis, Escherichia coli and Enterobacter aerogenes. The analysis of well and tap water to score and identifying the target protozoan parasites and coliform bacterial-species had been achieved before and after treatment with anti-parasitic and anti-bacterial compounds, that including chlorine and chloramines compounds, to reveal the effectiveness of these compounds against these contaminators, and from another view to ensure safety of these compounds to human health. After purifying the target water, or at least reducing it, from the present contaminators, field-application of chloramines must achieve instead of chlorine in the Public water tank and water pipe of Rafha City, in cooperation with Water Company in Rafha, to connect drinking water devoid of protozoan parasites and coliform bacteria and conform with specifications of the WHO to Raffia’s citizens.