Candidiasis or thrush is a fungal infection (mycosis) of  Candida species,  Candida albicans being  the most common^. The dimorphic fungus Candida albicans is a commensal of the human oral, gastrointestinal, vaginal, cutaneous, and mucosal surfaces. In immunocompetent as well as immunocompromised individuals,C. albicans causes cutaneous or subcutaneous infections such as vaginitis or oral thrush or infections of the nails and skin. Catheters and other medical implants and devices serve as an excellent substrate for biofilm formation and can act as a source of nosocomial infections. Fluconazole and Itraconazole  are  well-established drugs of choice for both localized and systemic C. albicans infections. However, prolonged use of these drugs could lead  to the development of drug resistant strains of  C .albicans. The present study deals with understanding the  antimycotic effect of both garlic and fluconazole on Candida albicans. Both aqueous and organic extracts of garlic are compared for their antimycotic activity along with Fluconazole. The use of natural antimycotics in synergism with Azole drugs in the treatment of Candida infections has also been investigated in order to make the treatment of Candida infections more cost effective and  reduce the possibility of pathogenic Candida albicans strains from becoming drug resistant to the conventional anti mycotic drugs.