Antifungal Activity of the Native Essential oil of Thymus vulgaris on Candida albicans, Aspergillus niger and Aspergillus flavus from Iran

ISSN: 0973-7510

E-ISSN: 2581-690X

Antifungal Activity of the Native Essential oil of Thymus vulgaris on Candida albicans, Aspergillus niger and Aspergillus flavus from Iran

N. Rahimifard^1,2, Sh. Shoeibi^1,2 , O. Sabzevari³, S.R. Pakzad^1,2, S. Ajdary⁴, M. Pirali Hamedani^1,2, H. Hajimehdipoor^1,2, F. Bagheri⁵ and B. Esmaeili⁵

¹Food and Drug Laboratory Research center (FDLRC), Tehran, Iran.

²Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH), Tehran, Iran.

³Pharmacy faculty, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

⁴Immunology Department, Pasteur Institute, Tehran, Iran.

⁵Microbiology Department, Pharmaceutical sciences branch, Islamic Azad University, Tehran, Iran.

J Pure Appl Microbiol. 2008;2(2):343-346

Received: 11/04/2008 | Accepted: 08/08/2008 | Published: 31/10/2008

Abstract

The composition of the native essential oil of Thymus vulgaris and its antifungal activity on Candida albicans, Aspergillus niger and Aspergillus flavusfungal strains were studied in Iran. Essential oil from the aerial parts of the plant was obtained by hydrodistillation and analysed by GC and GC-MS. The oil showed high contents of carvacrol and thymol. The MIC was used to evaluate the antifungal activity against Candida albicans ATCC 10231, Aspergillus niger ATCC 9642 and Aspergillus flavus ATCC 9643. Antifungal activity was evaluated for the essential oil and simultaneously for Amphotricin B. Results showed that Thymus vulgaris essential oil exhibited a significant activity against fungi, and its MIC on Candida albicans, Aspergillus niger and Aspergillus flavus were respectively 0.30, 0.15 and 0.25 µg ml^-1(ppm). The present study indicates that Thymus vulgaris essential oil has considerable antifungal activity,deserving further investigation for clinical applications.

Keywords

Thymus vulgaris, MIC, Antifungal activity

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