Androgenic Anabolic Activities of Some Substituted Androstan[16,17-c]pyrazoline and Androstan [17,16-c]isoxazole Derivatives

ISSN: 0973-7510

E-ISSN: 2581-690X

Mohamed M. Abdulla¹, Abd El-Galil E. Amr^2,3, Mohamed A. Al-Omar², Azza A. Hussain⁴ and Mohamed S. Amer⁴

¹Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt.

²Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC),
College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

³Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt.

⁴Department of Chemistry, Faculty of Science, Zagazige University, Zagazige Egypt.

J Pure Appl Microbiol. 2014;8(Spl. Edn. 2):447-454

Received: 21/08/2014 | Accepted: 30/10/2014 | Published: 30/11/2014

Abstract

We herein report the androgenic-anabolic activities of some synthesized substituted androstano[17,16-c]pyrazoline (steroidal structure). Twenty six steroid derivatives 1-11 containing acetyl, ester, methoxy and oxazole moieties attached to a steroid moiety were conveniently synthesized and screened for their androgenic anabolic activities. Synthetic steroid structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent androgenic agents. The detailed synthetic pathways of obtained compounds and androgenic activities were reported.

Keywords

Steroid derivatives, androstanopyrazolines, androstanoisoxazoles, androgenic anabolic activities

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