The morphology of Acinetobacter species is Gram-negative, nonmotile, nonfermenting, Strictly aerobic, Oxidase negative, and Catalase positive. It usually results from an infectious agent and is nonpathogenic in healthy people. A. baumannii can survive, for a long time and spread quickly in a hospital setting. Acinetobacter baumannii can cause many infections, the most common of which are bloodstream infections and nosocomial pneumonia in severe patients. These infections have a high mortality rate & the global emergence of antibiotic-resistant strains from multiple classes has- reduced the number of drugs that still have activity against this pathogen. The lack of A. baumannii isolates that produce carbapenemase in addition to having a minimal inhibitory concentration of imipenem greater than carbapenem resistance. The overview of the prevalence of Acinetobacter in the Indian scenario and world scenario. Comparision between carbapenem resistance and multidrug resistance. According to the studies, carbapenem resistance is rapidly increasing. Infection with Acinetobacter is linked to high mortality and morbidity. According to our review, patients who have an infection with A. baumannii may be at an increased risk of dying. However, due to the confounding factors of illness severity, inappropriate impractical antimicrobial treatment, and small sample size, cautious interpretations are necessary. We covered the main factor that make A. baumannii such a prevalent nosocomial pathogen in this review, including such as its virulence components, desiccation resistance, and carbapenem resistance mechanisms. With the emergence of extended resistance to even more recent antibiotics, Acinetobacter species are rapidly proliferating. They can develop resistance much more quickly than other gram-negative organisms.