Mushrooms play essential role in preventing and treating various health issues, including, Reducing swellings due to allergy, blood pressure, and high cholesterol level”. Mushrooms contain high quality, proteins, polysaccharides, unsaturated fatty acids, mineral substances, triterpenes, and secondary metabolites. Mushrooms are an excellent supplier of essential micronutrients and bioactive chemicals that may help to avoid chronic illnesses. Mushrooms have long been thought of as food that promote health. Recent research also indicates involvement of medicinal and culinary mushrooms in preventing a variety of age-related neurological dysfunctions, such as Parkinson’s illnesses and Alzheimer’s disease. Medicinal and edible mushrooms are rich in anti-tumor, and their antioxidant properties are extensively researched due to their various curative properties. Edible and medicinal mushrooms are used to prevent cancer to some extent and to minimize the side effects of conventional treatments like chemotherapy. Overall, mushrooms act as immunity booster, a good alternative for trace element supplement, and easily available to the consumers. In the present review, we discuss various benefits of mushrooms using recent studies.