ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Abdulrazzaq N. Zghair, Nazar Sh. Mohammed and Sumayah Faruq Kasim
College of Health and Medical Techniques, Middle Technical University, Baghdad, Iraq.
Article Number: 8214 | © The Author(s). 2023
J Pure Appl Microbiol. 2023;17(2):819-825. https://doi.org/10.22207/JPAM.17.2.08
Received: 06 November 2022 | Accepted: 18 March 2023 | Published online: 17 April 2023
Issue online: June 2023
Abstract

Infection with the hepatitis C virus (HCV) is serious and may lead to death. Venous blood samples were collected from HCV-infected patients (n=60) and from people without infection (n=60) as controls. These patients visited the Digestive System and Liver Disease Hospital, Baghdad, Iraq, during the period from 1st February to 1st November 2021. The results revealed no significant difference between males (31; 50.8%) and females(29; 49.2%) HCV-infected patients. The highest infection rate (55.6%) was observed among the 50–78 years age group, then 53.7% among the 25–49 years age group, then 36.7% among the 5–24 years age group with a significant difference (P=0.2). A highly significant difference was observed in the mean glutamic-pyruvic transaminase levels between HCV-infected patients (25.56±12.45) and the controls (17.86±4.91) (P=0.01), and a significant difference was observed in the mean glutamic-oxaloacetic transaminase levels between HCV-infected patients (21.70±8.63) and the controls (15.93±4.35) (P=0.02). A highly significant difference was demonstrated in mean alkaline phosphatase levels between HCV-infected patients (362.15±113.60) and controls (197.81±34.70)(P=0.001). Overall, we found that blood markers could aid in disease diagnosis and prognosis rather than mutations within the nonstructural 5A.1 hot spot. The frequency of mutations within this site was found to be very low.

Keywords

Sequence, Hepatitis C Virus (HCV), Liver diseases

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© The Author(s) 2023. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.