Rice (Oryza sativa L.) is the fastest growing staple food and cereal crop in Pakistan. Seed priming is a low-cost, low-risk technique that is easily adopted by resource-poor farmers in developing countries and increases the yield of crops. It improves seed performance, through increased seed vigor subsequent to enhanced percentage of seed germination and rates of seedling emergence. The effect of seed priming on germination percentage and mean time to germination of local and exotic cultivars of rice was studied. Effect of methanol leaf extract (10:100 w/v) of some weeds Cyperus esculentus (Della), Axonopus compressus (Itsit), Convulvulus arvensis (Lehli) and Parthenium hysterophorus (Parthenium) was assessed for their effect on rice seedling by laboratory experiments. In each Petri plate, ten seeds were placed and germination percentage and germination index of rice seeds was calculated. Weeds extracts priming increased germination rate and germination percentage as compare to control. An interaction affect on germination performance between vigor and priming was observed. The interaction between C. esculentus + P. hysterophorus showed increased germination percentage and growth enhancement in rice seedlings. Results showed that CDR448 (96%), Basmati-140 (84%), Begum-370 (80%) and Presidio (75%) were increased germination significantly among rice varieties. Conversely the seedling growth of Palman 60, Jhona-145, Ru8703196 and MAHIYA were least affected by weed extracts as compare to control. On the contrary, seed primed with weed extracts was non-significant in case of Raxmonth.  The overall study indicated that seed priming technique with weed extracts proved to be the most effective to germination and seedling growth of rice.